InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Amhr2

Summary

InnateDB Protein

IDBP-188639.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Amhr2

Protein Name

anti-Mullerian hormone type 2 receptor

Synonyms

Misiir; Misrii; Mrii;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023809

InnateDB Gene

IDBG-188637 (Amhr2)

Protein Structure

UniProt Annotation

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004872	receptor activity
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005026	transforming growth factor beta receptor activity, type II
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042562	hormone binding
GO:0046872	metal ion binding
GO:1990272	anti-Mullerian hormone receptor activity

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007548	sex differentiation
GO:0023014	signal transduction by phosphorylation
GO:1902613	negative regulation of anti-Mullerian hormone signaling pathway
GO:1990262	anti-Mullerian hormone signaling pathway

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:105062

InterPro

IPR000472 TGF-beta receptor/activin receptor, type I/II
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR015771 Anti-muellerian hormone receptor, type II
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF01064
PF00069
PF07714

PRINTS

PR00109

PIRSF

PIRSF037392

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References