InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SH3GL1

Summary

InnateDB Protein

IDBP-18867.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SH3GL1

Protein Name

SH3-domain GRB2-like 1

Synonyms

CNSA1; EEN; SH3D2B; SH3P8;

Species

Homo sapiens

Ensembl Protein

ENSP00000269886

InnateDB Gene

IDBG-18865 (SH3GL1)

Protein Structure

UniProt Annotation

Function

Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, podosome {ECO:0000269PubMed:23285027}. Note=Associated with postsynaptic endosomes in hippocampal neurons. {ECO:0000250}.

Disease Associations

Note=In some cases of acute leukemia, a translocation results in the formation of a KMT2A/MLL1-EEN fusion gene.

Tissue Specificity

Ubiquitous. Higher expression in pancreas, placenta, prostate, testis and uterus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	69 [view]
Protein-Protein	69 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0019902	phosphatase binding
GO:0042802	identical protein binding
GO:0051020	GTPase binding