InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Elovl4

Summary

InnateDB Protein

IDBP-188679.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Elovl4

Protein Name

elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034796

InnateDB Gene

IDBG-188677 (Elovl4)

Protein Structure

UniProt Annotation

Function

Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs) (By similarity). Seems to represent a photoreceptor-specific component of the fatty acid elongation system residing on the endoplasmic reticulum. May play a critical role in early brain and skin development (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in the retina, exclusively in photoreceptor cells and in the brain, skin, testis and lens. {ECO:0000269PubMed:15028285}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016740	transferase activity

Biological Process

GO:0019367	fatty acid elongation, saturated fatty acid
GO:0042761	very long-chain fatty acid biosynthetic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0030176	integral component of endoplasmic reticulum membrane