InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ttk

Summary

InnateDB Protein

IDBP-188735.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ttk

Protein Name

Ttk protein kinase

Synonyms

AL022661; esk; Esk1; Mps1; PYT;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000064839

InnateDB Gene

IDBG-188733 (Ttk)

Protein Structure

UniProt Annotation

Function

Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint (By similarity). Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. May play some role in the control of cell proliferation or differentiation and could be involved in modulating different levels of signal transduction pathways. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Present in rapidly proliferating cell lines; high levels in testis, bone marrow, spleen and thymus. Low levels in brain, heart, lung and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007093	mitotic cell cycle checkpoint
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0051304	chromosome separation

Cellular Component

GO:0016020

membrane

Protein Structure and Domains

PDB ID

MGI:1194921

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt