InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLRK1

Summary

InnateDB Protein

IDBP-18875.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLRK1

Protein Name

killer cell lectin-like receptor subfamily K, member 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000240618

InnateDB Gene

IDBG-237489 (KLRK1)

Protein Structure

UniProt Annotation

Function

Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. {ECO:0000269PubMed:10426994, ECO:0000269PubMed:11224526, ECO:0000269PubMed:11777960, ECO:0000269PubMed:15240696, ECO:0000269PubMed:21898152, ECO:0000269PubMed:23298206}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:10426994, ECO:0000269PubMed:11015446, ECO:0000269PubMed:15294961}; Single- pass type II membrane protein {ECO:0000269PubMed:10426994, ECO:0000269PubMed:11015446, ECO:0000269PubMed:15294961}. Note=Colocalized with HCST on the cell surface.

Disease Associations

Tissue Specificity

Expressed in natural killer (NK) cells, CD8(+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs). {ECO:0000269PubMed:10426993, ECO:0000269PubMed:15294961, ECO:0000269PubMed:16444266}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0007165	signal transduction
GO:0030101	natural killer cell activation
GO:0030154	cell differentiation
GO:0031295	T cell costimulation
GO:0045087	innate immune response
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0050776	regulation of immune response