InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eif2c4

Summary

InnateDB Protein

IDBP-188783.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eif2c4

Protein Name

eukaryotic translation initiation factor 2C, 4

Synonyms

5730550L01Rik; AI481660; Eif2c4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000081312

InnateDB Gene

IDBG-188779 (Eif2c4)

Protein Structure

UniProt Annotation

Function

Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. {ECO:0000255HAMAP-Rule:MF_03033, ECO:0000269PubMed:19174539}.

Subcellular Localization

Cytoplasm, P-body {ECO:0000255HAMAP- Rule:MF_03033}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.

Predicted by orthology
Total	62 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0035198	miRNA binding

Biological Process

GO:0006402	mRNA catabolic process
GO:0035278	negative regulation of translation involved in gene silencing by miRNA

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0016020	membrane
GO:0016442	RISC complex
GO:0035068	micro-ribonucleoprotein complex

Protein Structure and Domains

PDB ID

MGI:1924100

InterPro

IPR003100 Argonaute/Dicer protein, PAZ domain
IPR003165 Stem cell self-renewal protein Piwi
IPR012337 Ribonuclease H-like domain
IPR014811 Domain of unknown function DUF1785

PFAM

PF02170
PF02171
PF08699

PRINTS

PIRSF

SMART

SM00949
SM00950

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8CJF8