InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pcca

Summary

InnateDB Protein

IDBP-188898.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pcca

Protein Name

propionyl-Coenzyme A carboxylase, alpha polypeptide

Synonyms

C79630;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038763

InnateDB Gene

IDBG-188896 (Pcca)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Note=Propionic acidemia due to recessively inherited deficiency of PCCase activity often causes life-threatening ketosis and acidosis.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004075	biotin carboxylase activity
GO:0004658	propionyl-CoA carboxylase activity
GO:0005524	ATP binding
GO:0008716	D-alanine-D-alanine ligase activity
GO:0016874	ligase activity
GO:0019899	enzyme binding
GO:0046872	metal ion binding

Biological Process

GO:0008152	metabolic process
GO:0009405	pathogenesis

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

MGI:97499

InterPro

IPR000089 Biotin/lipoyl attachment
IPR003135 ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type
IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
IPR005481 Carbamoyl-phosphate synthase, large subunit, N-terminal
IPR005482 Biotin carboxylase, C-terminal
IPR008992 Enterotoxin, bacterial
IPR011053 Single hybrid motif
IPR011054 Rudiment single hybrid motif
IPR011095 D-alanine--D-alanine ligase, C-terminal
IPR011761 ATP-grasp fold
IPR011764 Biotin carboxylation domain
IPR013651 ATP-grasp fold, RimK-type
IPR016185 Pre-ATP-grasp domain

PFAM