Version 5.4
Mus musculus Protein: Thap11
Summary
InnateDB Protein IDBP-188901.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Thap11
Protein Name THAP domain containing 11
Synonyms 2810036E22Rik; AB041579; CTG-B43a; CTG-B45d; Ronin;
Species Mus musculus
Ensembl Protein ENSMUSP00000048994
InnateDB Gene IDBG-188899 (Thap11)
Protein Structure
UniProt Annotation
Function Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers. {ECO:0000269PubMed:18585351}.
Subcellular Localization Nucleus {ECO:0000269PubMed:18585351}. Cytoplasm {ECO:0000269PubMed:18585351}. Note=May be regulated by shuttling of the protein between the cytoplasm and nucleus.
Disease Associations
Tissue Specificity Mainly restricted to pluripotent cells of the developing embryo, to oocytes, and to certain regions of the adult brain. {ECO:0000269PubMed:18585351}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 0
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0045171 intercellular bridge
Protein Structure and Domains
PDB ID MGI:1930964
InterPro IPR006612 Zinc finger, C2CH-type
PFAM PF05485
PRINTS
PIRSF
SMART SM00692
SM00980
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JJD0
PhosphoSite PhosphoSite-Q9JJD0
TrEMBL
UniProt Splice Variant
Entrez Gene 59016
UniGene Mm.466724
RefSeq NP_067488
MGI ID
MGI Symbol Thap11
OMIM
CCDS CCDS22616
HPRD
IMGT
EMBL AB041579 AK165981 AK170457 BC003949 BC138966 BC138987 CH466525
GenPept AAH03949 AAI38967 AAI38988 BAA95063 BAE38498 BAE41810 EDL11318

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca