Version 5.4
Mus musculus Protein: Crlf2
Summary
InnateDB Protein IDBP-188985.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Crlf2
Protein Name cytokine receptor-like factor 2
Synonyms CRLM2; Ly114; Tpte2; Tslpr;
Species Mus musculus
Ensembl Protein ENSMUSP00000036326
InnateDB Gene IDBG-188983 (Crlf2)
Protein Structure
UniProt Annotation
Function Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system. {ECO:0000269PubMed:10974032}.
Subcellular Localization Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 3: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.
Disease Associations
Tissue Specificity High level of expression in liver, lung and testis. Also expressed in heart, brain, spleen, thymus and bone marrow. Highly expressed in progenitors and myeloid cells. Isoform 2 is expressed in primary hemotopoietic cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002380 immunoglobulin secretion involved in immune response
GO:0006954 inflammatory response
GO:0035745 T-helper 2 cell cytokine production
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1889506
InterPro IPR003961 Fibronectin, type III
PFAM PF00041
PF01108
PRINTS
PIRSF
SMART SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CII9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 57914
UniGene
RefSeq NP_057924
MGI ID 4NN7
MGI Symbol Crlf2
OMIM
CCDS CCDS19521
HPRD
IMGT
EMBL AB031333 AB039945 AF201963 AF232936 AK010291 BC023788
GenPept AAF81676 AAF82189 AAH23788 BAA92159 BAA92684 BAB26827

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca