InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyfip1

Summary

InnateDB Protein

IDBP-189036.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyfip1

Protein Name

cytoplasmic FMR1 interacting protein 1

Synonyms

E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1; mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032629

InnateDB Gene

IDBG-189032 (Cyfip1)

Protein Structure

UniProt Annotation

Function

Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers. {ECO:0000250, ECO:0000269PubMed:11438699, ECO:0000269PubMed:14765121, ECO:0000269PubMed:18805096, ECO:0000269PubMed:19524508}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11438699, ECO:0000269PubMed:14765121}. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cell projection, ruffle. Cell junction, synapse, synaptosome. Note=Highly expressed in the perinuclear region. Enriched in synaptosomes, membrane ruffles and at the tips of lamellipodia. {ECO:0000269PubMed:11438699, ECO:0000269PubMed:14765121}.

Disease Associations

Tissue Specificity

Highly expressed in embryonic and adult developing nervous system. {ECO:0000269PubMed:9756361}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005522	profilin binding
GO:0032403	protein complex binding
GO:0048365	Rac GTPase binding
GO:0051015	actin filament binding

Biological Process

GO:0008360	regulation of cell shape
GO:0016601	Rac protein signal transduction
GO:0030032	lamellipodium assembly
GO:0031529	ruffle organization
GO:0048675	axon extension
GO:0050890	cognition
GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005845	mRNA cap binding complex
GO:0030027	lamellipodium
GO:0030054	cell junction
GO:0031209	SCAR complex
GO:0043005	neuron projection
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome