Version 5.4
Mus musculus Protein: Npff
Summary
InnateDB Protein IDBP-189039.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Npff
Protein Name neuropeptide FF-amide peptide precursor
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000023814
InnateDB Gene IDBG-189037 (Npff)
Protein Structure
UniProt Annotation
Function Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels. {ECO:0000269PubMed:10798398}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0005184 neuropeptide hormone activity
Biological Process
GO:0002438 acute inflammatory response to antigenic stimulus
GO:0003254 regulation of membrane depolarization
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007218 neuropeptide signaling pathway
GO:0010459 negative regulation of heart rate
GO:0021510 spinal cord development
GO:0030103 vasopressin secretion
GO:0032099 negative regulation of appetite
GO:0042493 response to drug
GO:0043278 response to morphine
GO:0045777 positive regulation of blood pressure
GO:0046676 negative regulation of insulin secretion
GO:0051930 regulation of sensory perception of pain
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0060135 maternal process involved in female pregnancy
GO:0070253 somatostatin secretion
Cellular Component
GO:0005615 extracellular space
GO:0030425 dendrite
GO:0031982 vesicle
GO:0043204 perikaryon
GO:0043679 axon terminus
Protein Structure and Domains
PDB ID MGI:1891708
InterPro IPR008065 FMRFamide-related peptide
PFAM PF15085
PRINTS PR01682
PIRSF PIRSF038092
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WVA8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 54615
UniGene
RefSeq NP_061257
MGI ID
MGI Symbol Npff
OMIM
CCDS CCDS27887
HPRD
IMGT
EMBL AF148701
GenPept AAD39829

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca