InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHAF1A

Summary

InnateDB Protein

IDBP-18904.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHAF1A

Protein Name

chromatin assembly factor 1, subunit A (p150)

Synonyms

CAF-1; CAF1; CAF1B; CAF1P150; P150;

Species

Homo sapiens

Ensembl Protein

ENSP00000301280

InnateDB Gene

IDBG-18900 (CHAF1A)

Protein Structure

UniProt Annotation

Function

Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci (By similarity). Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. {ECO:0000250, ECO:0000269PubMed:12837248, ECO:0000269PubMed:15327775}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10052459}. Note=DNA replication foci.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 106 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	106 [view]
Protein-Protein	106 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0051082	unfolded protein binding
GO:0070087	chromo shadow domain binding

Biological Process

GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006335	DNA replication-dependent nucleosome assembly
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006461	protein complex assembly
GO:0007049	cell cycle
GO:0031497	chromatin assembly