InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Psmb2

Summary

InnateDB Protein

IDBP-189117.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Psmb2

Protein Name

proteasome (prosome, macropain) subunit, beta type 2

Synonyms

AU045357; AW108089; C7-I; D4Wsu33e; HC7-I;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030642

InnateDB Gene

IDBG-189115 (Psmb2)

Protein Structure

UniProt Annotation

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit has a chymotrypsin-like activity. {ECO:0000269PubMed:22341445}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Detected in liver (at protein level). {ECO:0000269PubMed:22341445}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	67 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004298	threonine-type endopeptidase activity
GO:0005515	protein binding

Biological Process

GO:0010243	response to organonitrogen compound
GO:0014070	response to organic cyclic compound
GO:0051603	proteolysis involved in cellular protein catabolic process