Version 5.4
Mus musculus Protein: Tfap2e
Summary
InnateDB Protein IDBP-189169.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tfap2e
Protein Name transcription factor AP-2, epsilon
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000035902
InnateDB Gene IDBG-189167 (Tfap2e)
Protein Structure
UniProt Annotation
Function Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation. {ECO:0000269PubMed:14572467, ECO:0000269PubMed:14636996, ECO:0000269PubMed:16684505}.
Subcellular Localization Nucleus {ECO:0000269PubMed:16684505}.
Disease Associations
Tissue Specificity Expressed most prominently in the mitral cell layer of the developing olfactory bulb and to a lesser extent in the granule cell layer. Also expressed in skin, articular cartilage, primary chondrocytes, and chondrosarcoma cell line SW1353. {ECO:0000269PubMed:14572467, ECO:0000269PubMed:14636996, ECO:0000269PubMed:16684505}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:2679630
InterPro IPR013854 Transcription factor AP-2, C-terminal
PFAM PF03299
PRINTS PR01748
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6VUP9
PhosphoSite PhosphoSite-Q6VUP9
TrEMBL
UniProt Splice Variant
Entrez Gene 332937
UniGene Mm.331881
RefSeq NP_945198
MGI ID
MGI Symbol Tfap2e
OMIM
CCDS CCDS18658
HPRD
IMGT
EMBL AL607129 AY325902
GenPept AAQ90059 CAM13972

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca