InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Psmb10

Summary

InnateDB Protein

IDBP-189175.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Psmb10

Protein Name

proteasome (prosome, macropain) subunit, beta type 10

Synonyms

Mecl-1; Mecl1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034369

InnateDB Gene

IDBG-189173 (Psmb10)

Protein Structure

UniProt Annotation

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Plays a role in determining the T-cell repertoire for an antiviral T-cell response. {ECO:0000269PubMed:22341445}.

Subcellular Localization

Cytoplasm {ECO:0000255PROSITE- ProRule:PRU00809}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in liver (at protein level). {ECO:0000269PubMed:22341445}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004298	threonine-type endopeptidase activity

Biological Process

GO:0000902	cell morphogenesis
GO:0042098	T cell proliferation
GO:0051603	proteolysis involved in cellular protein catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0005839	proteasome core complex
GO:1990111	spermatoproteasome complex

Protein Structure and Domains

PDB ID

MGI:1096380

InterPro

IPR000243 Peptidase T1A, proteasome beta-subunit
IPR001353 Proteasome, subunit alpha/beta
IPR024689 Proteasome beta subunit, C-terminal
IPR029055 Nucleophile aminohydrolases, N-terminal

PFAM

PF00227
PF12465

PRINTS

PR00141

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O35955