Version 5.4
Mus musculus Protein: Acmsd
Summary
InnateDB Protein IDBP-189194.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Acmsd
Protein Name amino carboxymuconate semialdehyde decarboxylase
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000048482
InnateDB Gene IDBG-189192 (Acmsd)
Protein Structure
UniProt Annotation
Function Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
Subcellular Localization
Disease Associations
Tissue Specificity Highest expression in kidney with lower levels in liver and brain. {ECO:0000269PubMed:12140278}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001760 aminocarboxymuconate-semialdehyde decarboxylase activity
GO:0003824 catalytic activity
GO:0046872 metal ion binding
Biological Process
GO:0008152 metabolic process
GO:0046874 quinolinate metabolic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2386323
InterPro IPR006992 Amidohydrolase 2
PFAM PF04909
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R519
PhosphoSite PhosphoSite-Q8R519
TrEMBL Q3TNK0
UniProt Splice Variant
Entrez Gene 266645
UniGene Mm.25735
RefSeq NP_001028213
MGI ID
MGI Symbol Acmsd
OMIM
CCDS CCDS15247
HPRD
IMGT
EMBL AB071419 AK143962 AK165228 BC139281
GenPept AAI39282 BAB86939 BAE25634 BAE38088

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca