InnateDB Protein
|
IDBP-189203.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Ncdn
|
Protein Name
|
neurochondrin
|
Synonyms
|
AU042419; mKIAA0607; MMS10-AE; Ms10ae; norbin;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000030637
|
InnateDB Gene
|
IDBG-189201 (Ncdn)
|
Protein Structure
|
|
Function |
Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)- calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth. {ECO:0000269PubMed:15790563, ECO:0000269PubMed:18572016, ECO:0000269PubMed:20007903}.
|
Subcellular Localization |
Cytoplasm, cytosol. Cell projection, dendrite. Note=Localizes to somatic regions of neurons. {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Expressed in the neuronal, chondral and bone tissues. Expressed in dendrites. Enriched in the brain in the surface layer I-IV. In brains, protein level increases in male but decreases in female with advancing age (at protein level). In adult brains, it is highly expressed in the forebrain and hindbrain. Highly expressed in the hippocampus, piriform cortex, septum, amygdaloid complex, medial geniculate nucleus, inferior colliculus, cerebellar nuclei and the nuclei of the Vth, VIIth, and XIIth cranial nerves. In bone tissues, it is expressed in osteoblasts and osteocytes. {ECO:0000269PubMed:11162505, ECO:0000269PubMed:11445285, ECO:0000269PubMed:15007648, ECO:0000269PubMed:20007903}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
11 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1347351
|
InterPro |
|
PFAM |
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9Z0E0
|
PhosphoSite |
PhosphoSite-Q9Z0E0
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
26562
|
UniGene |
Mm.475214
|
RefSeq |
NP_036116
|
MGI ID |
|
MGI Symbol |
Ncdn
|
OMIM |
|
CCDS |
CCDS18659
|
HPRD |
|
IMGT |
|
EMBL |
AB017608
AB017609
AB019041
AK002938
AK122327
AK154889
AK170502
AL606908
BC017126
|
GenPept |
AAH17126
BAA75226
BAA75227
BAA75228
BAA75229
BAB22468
BAC65609
BAE32905
BAE41841
CAM19265
|
|
|