Version 5.4
| Mus musculus Protein: Tpbg | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-189259.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Tpbg | ||||||||
| Protein Name | trophoblast glycoprotein | ||||||||
| Synonyms | 5T4; AW495680; WAIF1; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000006559 | ||||||||
| InnateDB Gene | IDBG-189257 (Tpbg) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a- dependent LRP6 internalization. {ECO:0000250}. | ||||||||
| Subcellular Localization | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Highly expressed in embryo and placenta. In adult, expressed only in brain and ovary. Not detected in kidney small intestine, heart, spleen, testis, liver, lung, thymus and stomach. {ECO:0000269PubMed:10366710}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1341264 | ||||||||
| InterPro |
IPR000372
Leucine-rich repeat-containing N-terminal IPR000483 Cysteine-rich flanking region, C-terminal IPR001611 Leucine-rich repeat IPR003591 Leucine-rich repeat, typical subtype |
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| PFAM |
PF01462
PF01463 PF00560 PF13504 PF13855 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00013
SM00082 SM00369 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q9Z0L0 | ||||||||
| PhosphoSite | PhosphoSite-Q9Z0L0 | ||||||||
| TrEMBL | Q8C7R8 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 21983 | ||||||||
| UniGene | Mm.484180 | ||||||||
| RefSeq | NP_035757 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Tpbg | ||||||||
| OMIM | |||||||||
| CCDS | CCDS23380 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AJ012160 AK049377 AK051162 AK143519 BC058198 | ||||||||
| GenPept | AAH58198 BAC33720 BAC34540 BAE25413 CAA09931 | ||||||||