InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hoxc13

Summary

InnateDB Protein

IDBP-189264.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hoxc13

Protein Name

homeobox C13

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001700

InnateDB Gene

IDBG-189262 (Hoxc13)

Protein Structure

UniProt Annotation

Function

Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes. {ECO:0000269PubMed:11290294, ECO:0000269PubMed:16835220}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in differentiating keratinocytes. In the hair follicle lower matrix, expressed in all 3 hair shaft- forming compartments, i.e. cuticle, cortex and medulla. Expression stops sharply at the boundary with the germinal matrix compartment. {ECO:0000269PubMed:11290294, ECO:0000269PubMed:16835220}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001942	hair follicle development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0009653	anatomical structure morphogenesis
GO:0009952	anterior/posterior pattern specification
GO:0035878	nail development
GO:0043587	tongue morphogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter