InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arhgef15

Summary

InnateDB Protein

IDBP-189311.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arhgef15

Protein Name

Rho guanine nucleotide exchange factor (GEF) 15

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000067684

InnateDB Gene

IDBG-189309 (Arhgef15)

Protein Structure

UniProt Annotation

Function

Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2. {ECO:0000269PubMed:21029865}.

Subcellular Localization

Cell projection, dendrite {ECO:0000269PubMed:21029865}. Note=Expressed exclusively in dendrites of the developing hippocampus.

Disease Associations

Tissue Specificity

At P12, expressed is detected in the CA1 region and the dentate gyrus of the hippocampus. {ECO:0000269PubMed:21029865}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0032319	regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0050790	regulation of catalytic activity
GO:0061299	retina vasculature morphogenesis in camera-type eye
GO:2000297	negative regulation of synapse maturation