InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rab3gap1

Summary

InnateDB Protein

IDBP-189320.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rab3gap1

Protein Name

RAB3 GTPase activating protein subunit 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000042070

InnateDB Gene

IDBG-189318 (Rab3gap1)

Protein Structure

UniProt Annotation

Function

Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Note=In neurons, it is enriched in the synaptic soluble fraction. {ECO:0000250}.

Disease Associations

Tissue Specificity

In the eye, it is highly expressed within the lens, particularly in the anterior lens epithelium and in a ring corresponding to the equatorial region where anterior cells are differentiating into lens fibers. Also highly expressed in the retina. {ECO:0000269PubMed:15696165}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005097	Rab GTPase activator activity
GO:0017137	Rab GTPase binding

Biological Process

GO:0007420	brain development
GO:0021854	hypothalamus development
GO:0032851	positive regulation of Rab GTPase activity
GO:0034389	lipid particle organization
GO:0043010	camera-type eye development
GO:0043087	regulation of GTPase activity
GO:0060325	face morphogenesis