InnateDB Protein
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IDBP-189323.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Nipa1
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Protein Name
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non imprinted in Prader-Willi/Angelman syndrome 1 homolog (human)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000053871
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InnateDB Gene
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IDBG-189321 (Nipa1)
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Protein Structure
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Function |
Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+). {ECO:0000269PubMed:17166836}.
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Subcellular Localization |
Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Early endosome {ECO:0000269PubMed:17166836}. Note=Recruited to the cell membrane in response to low extracellular magnesium.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Predominantly expressed in neuronal tissues. Brain, heart, kidney, liver and colon (at protein level). {ECO:0000269PubMed:14508708, ECO:0000269PubMed:17166836}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0015095
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magnesium ion transmembrane transporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2442058
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InterPro |
IPR008521
Magnesium transporter NIPA
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PFAM |
PF05653
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BHK1
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q3TLT5
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UniProt Splice Variant |
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Entrez Gene |
233280
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UniGene |
Mm.389901
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RefSeq |
NP_705806
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MGI ID |
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MGI Symbol |
Nipa1
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OMIM |
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CCDS |
CCDS21317
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HPRD |
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IMGT |
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EMBL |
AK046619
AK166325
AY098645
BC055828
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GenPept |
AAH55828
AAM34534
BAC32809
BAE38707
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