InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Col11a1

Summary

InnateDB Protein

IDBP-189349.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Col11a1

Protein Name

collagen, type XI, alpha 1

Synonyms

C530001D20Rik; cho;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000089793

InnateDB Gene

IDBG-189345 (Col11a1)

Protein Structure

UniProt Annotation

Function

May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000255PROSITE-ProRule:PRU00793}.

Disease Associations

Note=Defects in Col11a1 are associated with chondrodysplasia, an autosomal recessive disease characterized by skeletal defects caused by abnormalities in the cartilage of limbs, ribs, mandibles and trachea. {ECO:0000269PubMed:7859283}.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005201	extracellular matrix structural constituent
GO:0046872	metal ion binding

Biological Process

GO:0001502	cartilage condensation
GO:0001503	ossification
GO:0002063	chondrocyte development
GO:0003007	heart morphogenesis
GO:0006029	proteoglycan metabolic process
GO:0007601	visual perception
GO:0007605	sensory perception of sound
GO:0030199	collagen fibril organization
GO:0035989	tendon development
GO:0042472	inner ear morphogenesis
GO:0048704	embryonic skeletal system morphogenesis
GO:0048705	skeletal system morphogenesis
GO:0050910	detection of mechanical stimulus involved in sensory perception of sound
GO:0051216	cartilage development
GO:0055010	ventricular cardiac muscle tissue morphogenesis

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005581	collagen trimer
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

MGI:88446

InterPro

IPR000885 Fibrillar collagen, C-terminal
IPR001791 Laminin G domain
IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
IPR008160 Collagen triple helix repeat
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM

PF01410
PF00054
PF02210
PF00147
PF01391

PRINTS

PIRSF

SMART

SM00038
SM00210
SM00282
SM00186

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61245