InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Med20

Summary

InnateDB Protein

IDBP-189375.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Med20

Protein Name

Mediator of RNA polymerase II transcription subunit 20

Synonyms

1110011O05Rik; 2410115I17Rik; AU018348; Trfp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024778

InnateDB Gene

IDBG-606312 (Med20)

Protein Structure

UniProt Annotation

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0016455	RNA polymerase II transcription mediator activity

Biological Process

GO:0006350	transcription
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0008150	biological_process
GO:0035914	skeletal muscle cell differentiation