InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nalcn

Summary

InnateDB Protein

IDBP-189405.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nalcn

Protein Name

sodium leak channel, non-selective

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000201

InnateDB Gene

IDBG-189403 (Nalcn)

Protein Structure

UniProt Annotation

Function

Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. Activated either by neuropeptides substance P or neurotensin. Required for normal respiratory rhythm and neonatal survival. {ECO:0000269PubMed:17448995, ECO:0000269PubMed:19092807}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Widely expressed in the brain and spinal cord neurons. {ECO:0000269PubMed:17448995}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0005272	sodium channel activity
GO:0005515	protein binding

Biological Process

GO:0006811	ion transport
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0055085	transmembrane transport
GO:0070509	calcium ion import
GO:0086010	membrane depolarization during action potential