InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLRC3

Summary

InnateDB Protein

IDBP-18944.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLRC3

Protein Name

killer cell lectin-like receptor subfamily C, member 3

Synonyms

NKG2-E; NKG2E;

Species

Homo sapiens

Ensembl Protein

ENSP00000371328

InnateDB Gene

IDBG-18940 (KLRC3)

Protein Structure

UniProt Annotation

Function

Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

Subcellular Localization

Membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Natural killer cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0030246	carbohydrate binding

Biological Process

GO:0006968	cellular defense response
GO:0007165	signal transduction

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001304 C-type lectin
IPR008646 Herpesvirus UL45-like
IPR016187 C-type lectin fold

PFAM

PF00059
PF05473

PRINTS

PIRSF

SMART

SM00034

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q07444

PhosphoSite

PhosphoSite-Q07444

TrEMBL

UniProt Splice Variant

Entrez Gene

3823

UniGene

Hs.654362

RefSeq

NP_031359

HUGO

HGNC:6376

OMIM

602892

CCDS

CCDS31744

HPRD

04203

IMGT

EMBL

AC022075 AC068775 AF078550 AF350016 AF350017 AF461157 AJ001685 L14542

GenPept

AAA16833 AAD46108 AAK83803 AAK83804 AAL65232 CAA04923