InnateDB Protein
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IDBP-189495.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ncapd2
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Protein Name
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non-SMC condensin I complex, subunit D2
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Synonyms
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2810406C15Rik; 2810465G24Rik; CAP-D2; CNAP1; mKIAA0159;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000042260
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InnateDB Gene
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IDBG-189493 (Ncapd2)
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Protein Structure
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Function |
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Chromosome {ECO:0000250}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
18 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1915548
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InterPro |
IPR007673
Condensin subunit 1
IPR016024
Armadillo-type fold
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PFAM |
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PRINTS |
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PIRSF |
PIRSF017127
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8K2Z4
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PhosphoSite |
PhosphoSite-Q8K2Z4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
68298
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UniGene |
Mm.257590
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RefSeq |
NP_666283
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MGI ID |
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MGI Symbol |
Ncapd2
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OMIM |
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CCDS |
CCDS39636
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HPRD |
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IMGT |
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EMBL |
AK011352
AK019259
AK129068
BC006673
BC008592
BC025460
BC026982
BC029133
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GenPept |
AAH06673
AAH08592
AAH26982
AAH29133
BAB27560
BAB31633
BAC97878
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