InnateDB Protein
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IDBP-189543.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pawr
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Protein Name
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PRKC, apoptosis, WT1, regulator
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000092951
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InnateDB Gene
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IDBG-189541 (Pawr)
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Protein Structure
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Function |
Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis. Nuclear localization includes nucleoplasm and PML nuclear bodies (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
21 [view]
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0030889
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negative regulation of B cell proliferation
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GO:0042094
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interleukin-2 biosynthetic process
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GO:0042130
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negative regulation of T cell proliferation
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GO:0042986
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positive regulation of amyloid precursor protein biosynthetic process
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GO:0050860
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negative regulation of T cell receptor signaling pathway
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GO:0097190
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apoptotic signaling pathway
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Cellular Component |
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PDB ID |
MGI:2149961
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q925B0
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PhosphoSite |
PhosphoSite-Q925B0
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TrEMBL |
Q3UWE8
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UniProt Splice Variant |
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Entrez Gene |
114774
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UniGene |
Mm.391419
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RefSeq |
NP_473397
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MGI ID |
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MGI Symbol |
Pawr
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OMIM |
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CCDS |
CCDS36053
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HPRD |
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IMGT |
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EMBL |
AF377871
AK136412
DQ363525
DQ449073
DQ449074
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GenPept |
AAK55414
ABC96645
ABE27591
ABE27592
BAE22967
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