Version 5.4
| Mus musculus Protein: Gpr84 | |||||||
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| Summary | |||||||
| InnateDB Protein | IDBP-189551.6 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Gpr84 | ||||||
| Protein Name | G protein-coupled receptor 84 | ||||||
| Synonyms | EX33; | ||||||
| Species | Mus musculus | ||||||
| Ensembl Protein | ENSMUSP00000078753 | ||||||
| InnateDB Gene | IDBG-189549 (Gpr84) | ||||||
| Protein Structure |
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| UniProt Annotation | |||||||
| Function | Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system (By similarity). {ECO:0000250}. | ||||||
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. | ||||||
| Disease Associations | |||||||
| Tissue Specificity | Expressed predominantly in hematopoietic tissues. Expressed mainly in the bone marrow with transcripts also detected in spleen, the lymph node, liver and the lung. {ECO:0000269PubMed:11273702, ECO:0000269PubMed:16966319}. | ||||||
| Comments | |||||||
| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||
| PDB ID | MGI:1934129 | ||||||
| InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like IPR017452 GPCR, rhodopsin-like, 7TM IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx IPR019430 7TM GPCR, serpentine receptor class x (Srx) |
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| PFAM |
PF00001
PF10320 PF10328 |
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| PRINTS |
PR00237
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| PIRSF | |||||||
| SMART | |||||||
| TIGRFAMs | |||||||
| Post-translational Modifications | |||||||
| Modification | |||||||
| Cross-References | |||||||
| SwissProt | Q8CIM5 | ||||||
| PhosphoSite | PhosphoSite-Q8CIM5 | ||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 80910 | ||||||
| UniGene | Mm.419103 | ||||||
| RefSeq | NP_109645 | ||||||
| MGI ID | |||||||
| MGI Symbol | Gpr84 | ||||||
| OMIM | |||||||
| CCDS | CCDS27902 | ||||||
| HPRD | |||||||
| IMGT | |||||||
| EMBL | AF272948 BC023249 | ||||||
| GenPept | AAH23249 AAK01859 | ||||||