Version 5.4
Mus musculus Protein: Pgam5
Summary
InnateDB Protein IDBP-189565.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pgam5
Protein Name phosphoglycerate mutase family member 5
Synonyms 2610528A17Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000057760
InnateDB Gene IDBG-189563 (Pgam5)
Protein Structure
UniProt Annotation
Function Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression (By similarity). Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore. {ECO:0000250, ECO:0000269PubMed:22265414}.
Subcellular Localization Mitochondrion outer membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0005096 GTPase activator activity
GO:0016791 phosphatase activity
GO:0032403 protein complex binding
Biological Process
GO:0016311 dephosphorylation
GO:0043547 positive regulation of GTPase activity
GO:0070266 necroptotic process
Cellular Component
GO:0005741 mitochondrial outer membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1919792
InterPro IPR013078 Histidine phosphatase superfamily, clade-1
IPR029033 Histidine phosphatase superfamily
PFAM PF00300
PRINTS
PIRSF
SMART SM00855
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BX10
PhosphoSite PhosphoSite-Q8BX10
TrEMBL
UniProt Splice Variant
Entrez Gene 72542
UniGene Mm.61682
RefSeq NP_082549
MGI ID
MGI Symbol Pgam5
OMIM
CCDS CCDS19523
HPRD
IMGT
EMBL AK012159 AK034588 AK049246 AK146216 AK169643 BC052179 BC138924 BC138925
GenPept AAH52179 AAI38925 AAI38926 BAB28067 BAC28763 BAC33634 BAE26984 BAE41272

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca