InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mdfi

Summary

InnateDB Protein

IDBP-189570.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mdfi

Protein Name

MyoD family inhibitor

Synonyms

I-mf; I-mfa;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000069915

InnateDB Gene

IDBG-189568 (Mdfi)

Protein Structure

UniProt Annotation

Function

Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways. {ECO:0000269PubMed:11238923, ECO:0000269PubMed:12192039, ECO:0000269PubMed:8797820, ECO:0000269PubMed:9799236}.

Subcellular Localization

Nucleus. Cytoplasm.

Disease Associations

Tissue Specificity

In the embryo, highly expressed in the sclerotome. Also expressed in the notochord, neural tube, limb buds, heart, branchial arches and head mesenchyme. In the adult, highly expressed in skeletal muscle. Expressed at lower levels in most other tissues. {ECO:0000269PubMed:8797820}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 102 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	102 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0007257	activation of JUN kinase activity
GO:0009950	dorsal/ventral axis specification
GO:0030111	regulation of Wnt signaling pathway
GO:0030178	negative regulation of Wnt signaling pathway
GO:0043392	negative regulation of DNA binding
GO:0048704	embryonic skeletal system morphogenesis
GO:0060707	trophoblast giant cell differentiation