InnateDB Protein
|
IDBP-189572.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Mdfi
|
Protein Name
|
MyoD family inhibitor
|
Synonyms
|
I-mf; I-mfa;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000037888
|
InnateDB Gene
|
IDBG-189568 (Mdfi)
|
Protein Structure
|
|
Function |
Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways. {ECO:0000269PubMed:11238923, ECO:0000269PubMed:12192039, ECO:0000269PubMed:8797820, ECO:0000269PubMed:9799236}.
|
Subcellular Localization |
Nucleus. Cytoplasm.
|
Disease Associations |
|
Tissue Specificity |
In the embryo, highly expressed in the sclerotome. Also expressed in the notochord, neural tube, limb buds, heart, branchial arches and head mesenchyme. In the adult, highly expressed in skeletal muscle. Expressed at lower levels in most other tissues. {ECO:0000269PubMed:8797820}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 102 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
|
Protein-Protein |
4
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
102 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0000122
|
negative regulation of transcription from RNA polymerase II promoter
|
GO:0007257
|
activation of JUN kinase activity
|
GO:0009950
|
dorsal/ventral axis specification
|
GO:0030111
|
regulation of Wnt signaling pathway
|
GO:0030178
|
negative regulation of Wnt signaling pathway
|
GO:0043392
|
negative regulation of DNA binding
|
GO:0048704
|
embryonic skeletal system morphogenesis
|
GO:0060707
|
trophoblast giant cell differentiation
|
|
Cellular Component |
|
PDB ID |
MGI:107687
|
InterPro |
|
PFAM |
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P70331
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
D3Z3N7
|
UniProt Splice Variant |
|
Entrez Gene |
17240
|
UniGene |
Mm.329100
|
RefSeq |
NP_034913
|
MGI ID |
|
MGI Symbol |
Mdfi
|
OMIM |
|
CCDS |
CCDS50134
|
HPRD |
|
IMGT |
|
EMBL |
AC113536
BC006018
BC010259
BC083058
BC085233
U57820
U57821
U57822
|
GenPept |
AAC52791
AAC52792
AAC52793
AAH06018
AAH10259
AAH83058
AAH85233
|
|
|