InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Itga5

Summary

InnateDB Protein

IDBP-189592.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itga5

Protein Name

integrin alpha 5 (fibronectin receptor alpha)

Synonyms

Cd49e; Fnra; VLA5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023128

InnateDB Gene

IDBG-189590 (Itga5)

Protein Structure

UniProt Annotation

Function

Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. May play a role in the survival of adult skeletal muscle.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005154	epidermal growth factor receptor binding
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0007044	cell-substrate junction assembly
GO:0007155	cell adhesion
GO:0007157	heterophilic cell-cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007613	memory
GO:0010811	positive regulation of cell-substrate adhesion
GO:0030335	positive regulation of cell migration
GO:0031589	cell-substrate adhesion
GO:0033631	cell-cell adhesion mediated by integrin
GO:0035313	wound healing, spreading of epidermal cells
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:2000811	negative regulation of anoikis

Cellular Component

GO:0005737	cytoplasm
GO:0005911	cell-cell junction
GO:0005925	focal adhesion
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0032587	ruffle membrane
GO:0045202	synapse