InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nav3

Summary

InnateDB Protein

IDBP-189603.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nav3

Protein Name

neuron navigator 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032719

InnateDB Gene

IDBG-189601 (Nav3)

Protein Structure

UniProt Annotation

Function

May regulate IL2 production by T-cells. May be involved in neuron regeneration. {ECO:0000269PubMed:12062803}.

Subcellular Localization

Nucleus outer membrane {ECO:0000269PubMed:12062803}.

Disease Associations

Tissue Specificity

Present in neurons from central and peripheral nervous systems (at protein level). Highly expressed in brain cortex, midbrain, cerebellum and hippocampus. {ECO:0000269PubMed:12062803}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0008150	biological_process
GO:0008152	metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005640	nuclear outer membrane

Protein Structure and Domains

PDB ID

MGI:2183703

InterPro

IPR001715 Calponin homology domain
IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00307
PF00004
PF07724
PF13304

PRINTS

PIRSF

SMART

SM00033
SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q80TN7