Version 5.4
Mus musculus Protein: Tmem107
Summary
InnateDB Protein IDBP-189690.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmem107
Protein Name transmembrane protein 107
Synonyms 1110004B13Rik; 2810049P21Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000075363
InnateDB Gene IDBG-189688 (Tmem107)
Protein Structure
UniProt Annotation
Function Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types. {ECO:0000269PubMed:22698544}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations Note=Defect in TMEM107 is the cause of the schlei phenotype. Schlei mice display Shh-related defects including, preaxial polydactyly, exencephaly, and disrupted ventral neural tube patterning. Mice shown decreased numbers of cilia in several developing tissues and organs. However, nodal cilia appear normal in schlei mutants and subsequently, no left-right defects are obseved.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0021532 neural tube patterning
GO:0042384 cilium assembly
GO:0042733 embryonic digit morphogenesis
Cellular Component
GO:0005575 cellular_component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1914160
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CPV0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 66910
UniGene Mm.33964
RefSeq NP_080114
MGI ID
MGI Symbol Tmem107
OMIM
CCDS CCDS24879
HPRD
IMGT
EMBL AK003403 AK012938 AK154279 AL645902 BC096686 BC120499 BC137584
GenPept AAH96686 AAI20500 AAI37585 BAB22768 BAB28560 BAE32485 CAI24444 CAI24445

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca