InnateDB Protein
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IDBP-189692.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Tmem107
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Protein Name
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transmembrane protein 107
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Synonyms
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1110004B13Rik; 2810049P21Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000091624
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InnateDB Gene
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IDBG-189688 (Tmem107)
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Protein Structure
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Function |
Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types. {ECO:0000269PubMed:22698544}.
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Subcellular Localization |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
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Disease Associations |
Note=Defect in TMEM107 is the cause of the schlei phenotype. Schlei mice display Shh-related defects including, preaxial polydactyly, exencephaly, and disrupted ventral neural tube patterning. Mice shown decreased numbers of cilia in several developing tissues and organs. However, nodal cilia appear normal in schlei mutants and subsequently, no left-right defects are obseved.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1914160
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9CPV0
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
66910
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UniGene |
Mm.33964
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RefSeq |
NP_082612
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MGI ID |
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MGI Symbol |
Tmem107
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OMIM |
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CCDS |
CCDS24880
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HPRD |
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IMGT |
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EMBL |
AK003403
AK012938
AK154279
AL645902
BC096686
BC120499
BC137584
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GenPept |
AAH96686
AAI20500
AAI37585
BAB22768
BAB28560
BAE32485
CAI24444
CAI24445
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