Version 5.4
Mus musculus Protein: Pla2g15
Summary
InnateDB Protein IDBP-189713.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pla2g15
Protein Name phospholipase A2, group XV
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000034377
InnateDB Gene IDBG-189711 (Pla2g15)
Protein Structure
UniProt Annotation
Function Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N- acetylsphingosine and the concomitant release of a lyso- phospholipid. {ECO:0000269PubMed:11790796}.
Subcellular Localization Secreted {ECO:0000250}. Lysosome.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008374 O-acyltransferase activity
GO:0047499 calcium-independent phospholipase A2 activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006672 ceramide metabolic process
GO:0046470 phosphatidylcholine metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005739 mitochondrion
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2178076
InterPro IPR003386 Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase
IPR029058 Alpha/Beta hydrolase fold
PFAM PF02450
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VEB4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 192654
UniGene Mm.284770
RefSeq NP_598553
MGI ID
MGI Symbol Pla2g15
OMIM
CCDS CCDS22630
HPRD
IMGT
EMBL AF468958 AK085194 AK155004 AK163111 AK170814 AY179884 BC019373
GenPept AAH19373 AAL78651 AAO49009 BAC39387 BAE32987 BAE37197 BAE42046

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca