Version 5.4
Mus musculus Protein: Slc7a6
Summary
InnateDB Protein IDBP-189755.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc7a6
Protein Name solute carrier family 7 (cationic amino acid transporter, y+ system), member 6
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000034378
InnateDB Gene IDBG-189753 (Slc7a6)
Protein Structure
UniProt Annotation
Function Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis via transport of L-arginine. Involved in the transport of L- arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial cells (By similarity). {ECO:0000250}.
Subcellular Localization Basolateral cell membrane {ECO:0000250UniProtKB:Q92536}; Multi-pass membrane protein {ECO:0000250UniProtKB:Q92536}.
Disease Associations
Tissue Specificity Strongest expression in brain but also detected in testis, parotis, small intestine, heart and kidney. Weakly expressed in spleen, lung and liver. {ECO:0000269PubMed:10903140}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0015171 amino acid transmembrane transporter activity
GO:0015297 antiporter activity
Biological Process
GO:0003333 amino acid transmembrane transport
GO:0006810 transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
Protein Structure and Domains
PDB ID MGI:2142598
InterPro IPR002293 Amino acid/polyamine transporter I
IPR004841 Amino acid permease/ SLC12A domain
PFAM PF13520
PF00324
PRINTS
PIRSF PIRSF006060
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BGK6
PhosphoSite PhosphoSite-Q8BGK6
TrEMBL
UniProt Splice Variant
Entrez Gene 330836
UniGene Mm.412412
RefSeq NP_848913
MGI ID
MGI Symbol Slc7a6
OMIM
CCDS CCDS22631
HPRD
IMGT
EMBL AK049478 AK053899 AK129099 AK157127 AK164666 AK165629 AK165979 BC038404
GenPept AAH38404 BAC33770 BAC35581 BAC97909 BAE33971 BAE37866 BAE38304 BAE38497

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca