InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITGA11

Summary

InnateDB Protein

IDBP-18979.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGA11

Protein Name

integrin, alpha 11

Synonyms

HsT18964;

Species

Homo sapiens

Ensembl Protein

ENSP00000327290

InnateDB Gene

IDBG-18977 (ITGA11)

Protein Structure

UniProt Annotation

Function

Integrin alpha-11/beta-1 is a receptor for collagen.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

According to PubMed:10464311, highest levels of expression in uterus and heart, intermediate levels in skeletal muscle and intermediate to low levels in pancreas, kidney and placenta. According to PubMed:10486209, also found in brain, colon, lung, small intestine, stomach, testis, salivary glands, thyroid glands and prostate. Very low levels in peripheral blood lymphocytes, fetal brain and fetal liver. {ECO:0000269PubMed:10464311}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005518	collagen binding
GO:0038064	collagen receptor activity
GO:0046872	metal ion binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0006929	substrate-dependent cell migration
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007517	muscle organ development
GO:0030198	extracellular matrix organization
GO:0033627	cell adhesion mediated by integrin
GO:0038065	collagen-activated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0008305	integrin complex
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000413 Integrin alpha chain
IPR002035 von Willebrand factor, type A
IPR013517 FG-GAP repeat
IPR013519 Integrin alpha beta-propellor
IPR013649 Integrin alpha-2

PFAM

PF00092
PF01839
PF14312
PF08441

PRINTS

PR01185

PIRSF

SMART

SM00327
SM00191

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt