InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trem1

Summary

InnateDB Protein

IDBP-189796.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trem1

Protein Name

triggering receptor expressed on myeloid cells 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038636

InnateDB Gene

IDBG-189794 (Trem1)

Protein Structure

UniProt Annotation

Function

Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	0
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0097110	scaffold protein binding

Biological Process

GO:0002374	cytokine secretion involved in immune response
GO:0016477	cell migration
GO:0030593	neutrophil chemotaxis
GO:0042107	cytokine metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0050755	chemokine metabolic process
GO:0070945	neutrophil mediated killing of gram-negative bacterium
GO:0072672	neutrophil extravasation