InnateDB Protein
|
IDBP-189816.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Treml4
|
Protein Name
|
triggering receptor expressed on myeloid cells-like 4
|
Synonyms
|
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000054121
|
InnateDB Gene
|
IDBG-189814 (Treml4)
|
Protein Structure
|
|
Function |
May participate in antigen presentation. Binds to late apoptotic, and necrotic cells, but not living or early apoptotic cells, but is not essential for uptake of dying cells by dendritic cells (DCs). {ECO:0000269PubMed:19155473, ECO:0000269PubMed:22210914}.
|
Subcellular Localization |
Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
|
Disease Associations |
|
Tissue Specificity |
Predominantly expressed in spleen, with highest levels on selected populations of macrophages, including red pulp macrophages, and on subsets of DCs, mostly on CD8A+ DCs (at protein level). Not expressed on lymphocytes, nor granulocytes (at protein level). {ECO:0000269PubMed:19155473, ECO:0000269PubMed:22210914}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1923239
|
InterPro |
IPR003599
Immunoglobulin subtype
IPR007110
Immunoglobulin-like domain
IPR013106
Immunoglobulin V-set domain
|
PFAM |
PF07686
|
PRINTS |
|
PIRSF |
|
SMART |
SM00409
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q3LRV9
|
PhosphoSite |
PhosphoSite-Q3LRV9
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
224840
|
UniGene |
Mm.131234
|
RefSeq |
NP_766211
|
MGI ID |
|
MGI Symbol |
Treml4
|
OMIM |
|
CCDS |
CCDS28862
|
HPRD |
|
IMGT |
|
EMBL |
AC166164
BC117091
BC137666
CH466559
DQ087185
DQ087186
DQ186654
DQ186655
|
GenPept |
AAI17092
AAI37667
ABA29758
ABA29759
ABA38681
ABA38682
EDL23604
|
|
|