Version 5.4
Mus musculus Protein: Dars
Summary
InnateDB Protein IDBP-189884.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dars
Protein Name aspartyl-tRNA synthetase
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000027602
InnateDB Gene IDBG-189882 (Dars)
Protein Structure
UniProt Annotation
Function Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004815 aspartate-tRNA ligase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006422 aspartyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2442544
InterPro IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb
IPR004364 Aminoacyl-tRNA synthetase, class II (D/K/N)
IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
IPR004523 Aspartyl-tRNA synthetases
IPR006195 Aminoacyl-tRNA synthetase, class II
IPR012340 Nucleic acid-binding, OB-fold
PFAM PF00152
PF01336
PRINTS PR01042
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q922B2
PhosphoSite PhosphoSite-Q922B2
TrEMBL
UniProt Splice Variant
Entrez Gene 226414
UniGene Mm.431446
RefSeq NP_803228
MGI ID
MGI Symbol Dars
OMIM
CCDS CCDS15253
HPRD
IMGT
EMBL AK151027 AK151897 AK152304 AK152562 AK153256 AK153299 AK169716 BC008638
GenPept AAH08638 BAE30045 BAE30780 BAE31110 BAE31315 BAE31847 BAE31881 BAE41327

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca