Version 5.4
Mus musculus Protein: Ppp1r1a
Summary
InnateDB Protein IDBP-189919.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppp1r1a
Protein Name protein phosphatase 1, regulatory (inhibitor) subunit 1A
Synonyms 0610038N18Rik; I-1;
Species Mus musculus
Ensembl Protein ENSMUSP00000023133
InnateDB Gene IDBG-189917 (Ppp1r1a)
Protein Structure
UniProt Annotation
Function Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004864 protein phosphatase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0005977 glycogen metabolic process
GO:0007165 signal transduction
GO:0043086 negative regulation of catalytic activity
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1889595
InterPro IPR008466 Protein phosphatase inhibitor, 1DARPP-32
PFAM PF05395
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9ERT9
PhosphoSite PhosphoSite-Q9ERT9
TrEMBL Q9CW88
UniProt Splice Variant
Entrez Gene 58200
UniGene Mm.143788
RefSeq NP_067366
MGI ID
MGI Symbol Ppp1r1a
OMIM
CCDS CCDS37237
HPRD
IMGT
EMBL AF281676 AK002813 BC025123
GenPept AAG15192 AAH25123 BAB22378

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca