InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nfya

Summary

InnateDB Protein

IDBP-189927.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nfya

Protein Name

nuclear transcription factor-Y alpha

Synonyms

AA407810; Cbf-b; SEZ-10; SEZ10;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000077853

InnateDB Gene

IDBG-189923 (Nfya)

Protein Structure

UniProt Annotation

Function

Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'- CCAAT-3' box motif found in the promoters of its target genes. NF- Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1. {ECO:0000269PubMed:24030830}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	7 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:2000036	regulation of stem cell maintenance
GO:2000648	positive regulation of stem cell proliferation