InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zdhhc17

Summary

InnateDB Protein

IDBP-189961.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zdhhc17

Protein Name

zinc finger, DHHC domain containing 17

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043279

InnateDB Gene

IDBG-189959 (Zdhhc17)

Protein Structure

UniProt Annotation

Function

Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. Has transforming activity. Mediates Mg(2+) transport. {ECO:0000269PubMed:15489887, ECO:0000269PubMed:15603741}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localized predominantly in the perinuclear regions of neurons from the cortex, striatum and hippocampus. Colocalized with HD in the medium spiny neurons of the striatum and the spiny neurons that project into the globus pallidus. {ECO:0000269PubMed:12393793}.

Disease Associations

Tissue Specificity

Expressed in liver, testis, kidney, heart, pancreas and brain. Highest expression was seen in the brain. {ECO:0000269PubMed:12393793}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0015095	magnesium ion transmembrane transporter activity
GO:0016409	palmitoyltransferase activity
GO:0019706	protein-cysteine S-palmitoyltransferase activity
GO:0042802	identical protein binding

Biological Process

GO:0007165	signal transduction
GO:0015693	magnesium ion transport
GO:0018345	protein palmitoylation
GO:0042953	lipoprotein transport
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0016021	integral component of membrane
GO:0030660	Golgi-associated vesicle membrane
GO:0043231	intracellular membrane-bounded organelle