InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vwf

Summary

InnateDB Protein

IDBP-189971.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vwf

Protein Name

Von Willebrand factor homolog

Synonyms

6820430P06Rik; AI551257; B130011O06Rik; C630030D09; F8VWF; VWD;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001995

InnateDB Gene

IDBG-189967 (Vwf)

Protein Structure

UniProt Annotation

Function

Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). {ECO:0000250UniProtKB:P04275}.

Subcellular Localization

Secreted {ECO:0000250}. Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Localized to storage granules. {ECO:0000250}.

Disease Associations

Tissue Specificity

Plasma. Expressed in liver. {ECO:0000269PubMed:14613933}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0002020	protease binding
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0019865	immunoglobulin binding
GO:0042803	protein homodimerization activity
GO:0047485	protein N-terminus binding
GO:0051087	chaperone binding

Biological Process

GO:0001889	liver development
GO:0001890	placenta development
GO:0007155	cell adhesion
GO:0007596	blood coagulation
GO:0007599	hemostasis
GO:0030168	platelet activation
GO:0031589	cell-substrate adhesion
GO:0051260	protein homooligomerization

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005783	endoplasmic reticulum
GO:0009897	external side of plasma membrane
GO:0031012	extracellular matrix
GO:0033093	Weibel-Palade body

Protein Structure and Domains

PDB ID

MGI:98941

InterPro

IPR001007 von Willebrand factor, type C
IPR001846 von Willebrand factor, type D domain
IPR002035 von Willebrand factor, type A
IPR002919 Trypsin Inhibitor-like, cysteine rich domain
IPR006207 Cystine knot, C-terminal
IPR006552 VWC out
IPR012011 von Willebrand factor
IPR014853 Uncharacterised domain, cysteine-rich
IPR029034 Cystine-knot cytokine

PFAM

PF00093
PF00094
PF00092
PF01826
PF08742

PRINTS

PIRSF

PIRSF002495

SMART

SM00214
SM00216
SM00327
SM00041
SM00215
SM00832

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt