InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLRC2

Summary

InnateDB Protein

IDBP-18998.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLRC2

Protein Name

killer cell lectin-like receptor subfamily C, member 2

Synonyms

CD159c; NKG2-C; NKG2C;

Species

Homo sapiens

Ensembl Protein

ENSP00000371327

InnateDB Gene

IDBG-18996 (KLRC2)

Protein Structure

UniProt Annotation

Function

Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

Subcellular Localization

Membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Natural killer cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0006968	cellular defense response
GO:0007165	signal transduction
GO:0045087	innate immune response

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001304 C-type lectin
IPR008646 Herpesvirus UL45-like
IPR016187 C-type lectin fold

PFAM

PF00059
PF05473

PRINTS

PIRSF

SMART

SM00034

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P26717

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

3822

UniGene

Hs.591157

RefSeq

NP_002251

HUGO

HGNC:6375

OMIM

602891

CCDS

CCDS31745

HPRD

04202

IMGT

EMBL

AC068775 AF260134 AJ001684 BC093644 BC112039 X54869 Y13055

GenPept

AAF86972 AAH93644 AAI12040 CAA04922 CAA38651 CAA73498