Version 5.4
Mus musculus Protein: Dbt
Summary
InnateDB Protein IDBP-190023.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dbt
Protein Name dihydrolipoamide branched chain transacylase E2
Synonyms D3Wsu60e;
Species Mus musculus
Ensembl Protein ENSMUSP00000000349
InnateDB Gene IDBG-190021 (Dbt)
Protein Structure
UniProt Annotation
Function The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component.
Subcellular Localization Mitochondrion matrix.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016746 transferase activity, transferring acyl groups
GO:0043754 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0015630 microtubule cytoskeleton
GO:0042645 mitochondrial nucleoid
Protein Structure and Domains
PDB ID MGI:105386
InterPro IPR000089 Biotin/lipoyl attachment
IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain
IPR004167 E3 binding
IPR011053 Single hybrid motif
PFAM PF00364
PF00198
PF02817
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P53395
PhosphoSite PhosphoSite-P53395
TrEMBL
UniProt Splice Variant
Entrez Gene 13171
UniGene Mm.462781
RefSeq NP_034152
MGI ID
MGI Symbol Dbt
OMIM
CCDS CCDS17787
HPRD
IMGT
EMBL AK165959 CH466532 L42996
GenPept AAC37681 BAE38487 EDL12381

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca