InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Psmc3

Summary

InnateDB Protein

IDBP-190084.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Psmc3

Protein Name

proteasome (prosome, macropain) 26S subunit, ATPase 3

Synonyms

TBP-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000071054

InnateDB Gene

IDBG-190080 (Psmc3)

Protein Structure

UniProt Annotation

Function

The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Cytoplasm, P-body {ECO:0000269PubMed:22078707}. Note=Colocalizes with TRIM5 in the cytoplasmic bodies.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 92 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	92 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0009378	four-way junction helicase activity
GO:0016787	hydrolase activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0001824	blastocyst development
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0030163	protein catabolic process

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0022624	proteasome accessory complex
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1098754

InterPro

IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR005937 26S proteasome subunit P45
IPR008824 DNA helicase, Holliday junction RuvB type, N-terminal
IPR011704 ATPase, dynein-related, AAA domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00004
PF07724
PF13304
PF05496
PF07728

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O88685