InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lrfn2

Summary

InnateDB Protein

IDBP-190094.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lrfn2

Protein Name

leucine rich repeat and fibronectin type III domain containing 2

Synonyms

5730420O05Rik; mKIAA1246; SALM1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047573

InnateDB Gene

IDBG-190092 (Lrfn2)

Protein Structure

UniProt Annotation

Function

Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A (By similarity). May play a role in redistributing DLG4 to the cell periphery. {ECO:0000250, ECO:0000269PubMed:16828986}.

Subcellular Localization

Membrane {ECO:0000269PubMed:16828986}; Single-pass type I membrane protein {ECO:0000269PubMed:16828986}. Cell junction, synapse {ECO:0000269PubMed:16828986}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominantly expressed in the brain, with a weak, but broad expression in the cerebral cortex and diencephalic nuclei. Strongly expressed in both the pyramidal layer and the dentate gyrus of the hippocampus. Also detected in other parts of the central nervous system, including the olfactory bulb, pons, cerebellum, and medulla oblongata, as well as in the peripheral nervous system, such as the ganglia of cranial nerves and the dorsal root ganglion during gestation. {ECO:0000269PubMed:16828986}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

Cellular Component

GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:1917780

InterPro

IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set

PFAM